Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

Eur Cardiol. 2019 Jul 11;14(2):117-122. doi: 10.15420/ecr.2019.17.2. eCollection 2019 Jul.


Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.

Keywords: Inflammation; cardiovascular risk factor; curcumin; lifestyle-related diseases; natural product.

Publication types

  • Review