Irreversible oxidative post-translational modifications in heart disease

Expert Rev Proteomics. 2019 Aug;16(8):681-693. doi: 10.1080/14789450.2019.1645602. Epub 2019 Jul 30.

Abstract

Introduction: Development of specific biomarkers aiding early diagnosis of heart failure is an ongoing challenge. Biomarkers commonly used in clinical routine usually act as readouts of an already existing acute condition rather than disease initiation. Functional decline of cardiac muscle is greatly aggravated by increased oxidative stress and damage of proteins. Oxidative post-translational modifications occur already at early stages of tissue damage and are thus regarded as potential up-coming disease markers. Areas covered: Clinical practice regarding commonly used biomarkers for heart disease is briefly summarized. The types of oxidative post-translational modification in cardiac pathologies are discussed with a special focus on available quantitative techniques and characteristics of individual modifications with regard to their stability and analytical accessibility. As irreversible oxidative modifications trigger protein degradation pathways or cause protein aggregation, both influencing biomarker abundance, a chapter is dedicated to their regulation in the heart.

Keywords: Heart failure; oxidative stress; post-translational modifications; protein aggregation; protein degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heart Diseases / metabolism*
  • Heart Failure / metabolism*
  • Humans
  • Oxidation-Reduction
  • Oxidative Stress / physiology
  • Protein Aggregation, Pathological / metabolism
  • Protein Processing, Post-Translational

Grant support

This paper was funded by the Austrian Science Fund, grant numbers: [F73], [J-3983], [KLI425], [KLI645], [P26074], [W1226] and the Austrian Herzfonds.