Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats

Braz J Cardiovasc Surg. 2019 Dec 1;34(6):674-679. doi: 10.21470/1678-9741-2018-0306.

Abstract

Objective: To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.

Methods: In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.

Results: Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group.

Conclusion: Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.

Keywords: Animal; Creatine Kinase; Disease Outbreaks; Hemodynamics; L-Lactate Dehydrogenase; Myocardial Reperfusion Injury; Rats; Troponin I.

MeSH terms

  • Animals
  • Creatine Kinase
  • Disease Models, Animal
  • Hemodynamics
  • Magnetic Fields / adverse effects*
  • Male
  • Myocardial Reperfusion Injury / physiopathology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Creatine Kinase

Grant support

Financial support: This study was funded by Research Institutes in Yunnan Medical and Health Units Project, 2016NS075, and The National Natural Science Foundation of China, 41764007.