Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading

Anticancer Res. 2019 Aug;39(8):4503-4509. doi: 10.21873/anticanres.13626.

Abstract

Background/aim: Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases.

Materials and methods: Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed.

Results: SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading.

Conclusion: Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.

Keywords: Hypertensive; Pantoea agglomerans-derived LPS; oral administration; salt loading.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Pressure / drug effects
  • Cytokines / genetics*
  • Disease Models, Animal
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / genetics
  • Hypertension / pathology
  • Lipopolysaccharides / administration & dosage*
  • Lipopolysaccharides / chemistry
  • Male
  • Pantoea / chemistry*
  • Phagocytosis / drug effects
  • Rats
  • Rats, Inbred SHR
  • Salts / toxicity

Substances

  • Cytokines
  • Lipopolysaccharides
  • Salts