Do not discard Staphylococcus aureus WTA as a vaccine antigen

doi:10.1038/s41586-019-1416-8

Comment

. 2019 Aug;572(7767):E1-E2.

doi: 10.1038/s41586-019-1416-8. Epub 2019 Jul 31.

Do not discard Staphylococcus aureus WTA as a vaccine antigen

Rob van Dalen¹, Michèle M Molendijk¹, Sara Ali², Kok P M van Kessel¹, Piet Aerts¹, Jos A G van Strijp¹, Carla J C de Haas¹, Jeroen Codée², Nina M van Sorge³

Affiliations

¹ University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
³ University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. nsorge3@umcutrecht.nl.

PMID: 31367020
DOI: 10.1038/s41586-019-1416-8

Comment

Do not discard Staphylococcus aureus WTA as a vaccine antigen

Rob van Dalen et al. Nature. 2019 Aug.

. 2019 Aug;572(7767):E1-E2.

doi: 10.1038/s41586-019-1416-8. Epub 2019 Jul 31.

Authors

Rob van Dalen¹, Michèle M Molendijk¹, Sara Ali², Kok P M van Kessel¹, Piet Aerts¹, Jos A G van Strijp¹, Carla J C de Haas¹, Jeroen Codée², Nina M van Sorge³

Affiliations

¹ University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
³ University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. nsorge3@umcutrecht.nl.

PMID: 31367020
DOI: 10.1038/s41586-019-1416-8

No abstract available

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Comment in

Reply to: Do not discard Staphylococcus aureus WTA as a vaccine antigen.
Gerlach D, Guo Y, Stehle T, Peschel A. Gerlach D, et al. Nature. 2019 Aug;572(7767):E3-E4. doi: 10.1038/s41586-019-1417-7. Nature. 2019. PMID: 31367019 No abstract available.

Comment on

Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity.
Gerlach D, Guo Y, De Castro C, Kim SH, Schlatterer K, Xu FF, Pereira C, Seeberger PH, Ali S, Codée J, Sirisarn W, Schulte B, Wolz C, Larsen J, Molinaro A, Lee BL, Xia G, Stehle T, Peschel A. Gerlach D, et al. Nature. 2018 Nov;563(7733):705-709. doi: 10.1038/s41586-018-0730-x. Epub 2018 Nov 21. Nature. 2018. PMID: 30464342

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References

1. Gerlach, D. et al. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature 563, 705–709 (2018). - DOI
1. Driguez, P. A. et al. Immunogenic compositions against S. aureus. WO patent WO/2017/064190 (2017).
1. Xia, G. et al. Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J. Biol. Chem. 285, 13405–13415 (2010). - DOI
1. Brown, S. et al. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc. Natl Acad. Sci. USA 109, 18909–18914 (2012). - DOI
1. Brown, E. J. et al. Anti-wall teichoic antibodies and conjugates. WO patent WO/2014/194247 (2015).

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[1] Gerlach, D. et al. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature 563, 705–709 (2018). - DOI

[2] Gerlach, D. et al. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature 563, 705–709 (2018). - DOI

[3] Driguez, P. A. et al. Immunogenic compositions against S. aureus. WO patent WO/2017/064190 (2017).

[4] Driguez, P. A. et al. Immunogenic compositions against S. aureus. WO patent WO/2017/064190 (2017).

[5] Xia, G. et al. Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J. Biol. Chem. 285, 13405–13415 (2010). - DOI

[6] Xia, G. et al. Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J. Biol. Chem. 285, 13405–13415 (2010). - DOI

[7] Brown, S. et al. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc. Natl Acad. Sci. USA 109, 18909–18914 (2012). - DOI

[8] Brown, S. et al. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc. Natl Acad. Sci. USA 109, 18909–18914 (2012). - DOI

[9] Brown, E. J. et al. Anti-wall teichoic antibodies and conjugates. WO patent WO/2014/194247 (2015).

[10] Brown, E. J. et al. Anti-wall teichoic antibodies and conjugates. WO patent WO/2014/194247 (2015).

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Do not discard Staphylococcus aureus WTA as a vaccine antigen

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