Aim: The purpose of this study was to evaluate and compare remineralization potential of fluoride, amorphous calcium phosphate-casein phosphopeptide (ACP-CPP), and combination of hydroxyapatite (HAP) and fluoride on enamel lesions.
Materials and methodology: Ten intact caries-free human premolars were selected. The coronal portion of each tooth was sectioned into four parts to make four enamel blocks. The baseline surface microhardness (SMH) was measured for all the enamel specimens using Vickers microhardness testing machine. The artificial carious lesion was created by immersing the specimens in demineralizing solution for 3 consecutive days at 35° The SMH of each specimen was evaluated. All the four enamel sections of each tooth were subjected to various surface treatments, i.e., Group A - Fluoride varnish, Group B - ACP-CPP, Group C - Combination of HAP and fluoride (Clinpro), and Group D - Control group; no surface treatment. A carious progress test (pH cycle) was carried out which consisted of alternative demineralization (3 h) and remineralization using artificial saliva (21 h.) for 5 consecutive days. After pH cycling, SMH readings of each specimen were again assessed to evaluate remineralization potential of each surface treatment agent.
Results: Data obtained were statistically analyzed using one-way ANOVA followed by Tukey-Kramer multiple comparison test which was applied to detect significant differences between different surface treatments at different phases of studies.
Conclusion: Fluoride varnish shows higher remineralization potential of early carious lesion compare to ACP-CPP and Clinpro.
Keywords: Amorphous calcium phosphate-casein phosphopeptide; Clinpro; demineralization-remineralization; fluoride.
Conflict of interest statement
There are no conflicts of interest.
Remineralization Potential of Fluoride and Amorphous Calcium Phosphate-Casein Phospho Peptide on Enamel Lesions: An in Vitro Comparative EvaluationS Lata et al. J Conserv Dent 13 (1), 42-6. PMID 20582219.With in the limits, the present study concludes that; ACP-CPP cream is effective, but to a lesser extent than fluoride in remineralizing early enamel caries at surface le …
Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride on Artificial Enamel White Spot Lesion: An in Vitro Light Fluorescence StudyR Mehta et al. Indian J Dent Res 24 (6), 681-9. PMID 24552927.
As compared with artificial saliva both CPP-ACP and CPP-ACFP produced significant amount of remineralization of the artificial enamel white spot lesion (P < 0.001), ho…
An in vitro Comparison of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste, Casein Phosphopeptide-Amorphous Calcium Phosphate Paste With Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate Varnish on the Inhibition of Demineralization and Promotion of Remineralization of EnamelPJ Thakkar et al. J Indian Soc Pedod Prev Dent 35 (4), 312-318. PMID 28914243.This study shows that CPP-ACPF varnish is effective in preventing demineralization as well as promoting remineralization of enamel. Thus, it can be used as an effective p …
Remineralization Potential of Bioactive Glass and Casein Phosphopeptide-Amorphous Calcium Phosphate on Initial Carious Lesion: An In-Vitro pH-cycling StudyAB Mehta et al. J Conserv Dent 17 (1), 3-7. PMID 24554851.Within the limits; the present study concluded that; both BAG and CPP-ACP are effective in remineralizing early enamel caries. Application of BAG more effectively reminer …
Anticariogenicity of Casein Phosphopeptide-Amorphous Calcium Phosphate: A Review of the LiteratureC Llena et al. J Contemp Dent Pract 10 (3), 1-9. PMID 19430620. - ReviewRemineralization of white spot lesions has been achieved clinically by applying pastes based on these compounds, and a similar effect to self-applied fluorides has been o …
- Margolis HC, Moreno EC. Composition and cariogenic potential of dental plaque fluid. Crit Rev Oral Biol Med. 1994;5:1–25. - PubMed
- Margolis HC, Zhang YP, van Houte J, Moreno EC. Effect of sucrose concentration on the cariogenic potential of pooled plaque fluid from caries-free and caries-positive individuals. Caries Res. 1993;27:467–73. - PubMed
- Silverstone LM. Structural alterations of human dental enamel during incipient carious lesion development. In: Rowe N, editor. Proceedings of Symposium on Incipient Caries of Enamel, Nov 11-12. Ann Arbor, MI: University of Michigan School of Dentistry; 1977. pp. 3–42.
- Mann AB, Dickinson ME. Nanomechanics, chemistry and structure at the enamel surface. Monogr Oral Sci. 2006;19:105–31. - PubMed
- Silverstone LM, Wefel JS, Zimmerman BF, Clarkson BH, Featherstone MJ. Remineralization of natural and artificial lesions in human dental enamel in vitro. Effect of calcium concentration of the calcifying fluid. Caries Res. 1981;15:138–57. - PubMed