Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum

Arthritis Rheum. 1988 Aug;31(8):1041-5. doi: 10.1002/art.1780310816.


Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor alpha (TNF alpha). Seven of 12 sera from RA patients contained TNF alpha, while only 1 of those from reactive arthritis patients was positive. Gamma-interferon was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor beta was not detected in any sera or synovial fluids. RA patients with detectable TNF alpha had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Arthritis / metabolism
  • Arthritis, Rheumatoid / metabolism*
  • Female
  • Humans
  • Interferon-gamma / analysis
  • Male
  • Synovial Fluid / analysis*
  • Tumor Necrosis Factor-alpha / analysis*


  • Tumor Necrosis Factor-alpha
  • Interferon-gamma