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, 18 (18), 2157-2163

The Mystery of the Ketogenic Diet: Benevolent Pseudo-Diabetes

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The Mystery of the Ketogenic Diet: Benevolent Pseudo-Diabetes

Mikhail V Blagosklonny. Cell Cycle.

Abstract

Designed a century ago to treat epilepsy, the ketogenic diet (KD) is also effective against obesity and diabetes. Paradoxically, some studies in rodents have found that the KD seemingly causes diabetes, contradicting solid clinical data in humans. This paradox can be resolved by applying the concept of starvation pseudo-diabetes, which was discovered in starved animals almost two centuries ago, and has also been observed in some rapamycin-treated rodents. Intriguingly, use of the KD and rapamycin is indicated for a similar spectrum of diseases, including Alzheimer's disease and cancer. Even more intriguingly, benevolent (starvation) pseudo-diabetes may counteract type 2 diabetes or its complications.

Keywords: Ketogenic diet; aging; fasting; mTOR; rapalogs; rapamycin.

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