PIN-FORMED and PIN-LIKES auxin transport facilitators

Development. 2019 Aug 1;146(15):dev168088. doi: 10.1242/dev.168088.


The phytohormone auxin influences virtually all aspects of plant growth and development. Auxin transport across membranes is facilitated by, among other proteins, members of the PIN-FORMED (PIN) and the structurally similar PIN-LIKES (PILS) families, which together govern directional cell-to-cell transport and intracellular accumulation of auxin. Canonical PIN proteins, which exhibit a polar localization in the plasma membrane, determine many patterning and directional growth responses. Conversely, the less-studied non-canonical PINs and PILS proteins, which mostly localize to the endoplasmic reticulum, attenuate cellular auxin responses. Here, and in the accompanying poster, we provide a brief summary of current knowledge of the structure, evolution, function and regulation of these auxin transport facilitators.

Keywords: Auxin; Auxin transport; Phytohormone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arabidopsis / growth & development*
  • Arabidopsis / metabolism
  • Arabidopsis Proteins / metabolism*
  • Cell Communication / physiology*
  • Indoleacetic Acids / metabolism*
  • Membrane Transport Proteins / metabolism*
  • Plant Development / physiology
  • Plant Growth Regulators / metabolism
  • Plant Proteins / metabolism
  • Protein Transport / physiology


  • AT5G01990.1 protein, Arabidopsis
  • Arabidopsis Proteins
  • Indoleacetic Acids
  • Membrane Transport Proteins
  • PIN1 protein, Arabidopsis
  • Plant Growth Regulators
  • Plant Proteins
  • indoleacetic acid