Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease

Kenneth S Hershon; Barbara R Hirsch; Ola Odugbesan

doi:10.2337/cd18-0040

Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease

Clin Diabetes. 2019 Jul;37(3):250-259. doi: 10.2337/cd18-0040.

Authors

Kenneth S Hershon¹, Barbara R Hirsch¹, Ola Odugbesan²

Affiliations

¹ North Shore Diabetes and Endocrine Associates, New Hyde Park, NY.
² North Atlanta Endocrinology and Diabetes, Lawrenceville, GA.

Abstract

IN BRIEF This article reviews the evidence regarding the impact of postprandial glucose (PPG) on overall A1C and its relation to cardiovascular disease (CVD). To date, four randomized, controlled trials have evaluated the impact of PPG reduction on CVD; however, only one of these successfully demonstrated a positive effect. Despite this, epidemiological evidence does indicate a cardiovascular benefit of PPG reduction, and agents that can be used to manage PPG in people with type 2 diabetes are also discussed.