Thyroid hormone therapy for hypothyroidism

Endocrine. 2019 Oct;66(1):18-26. doi: 10.1007/s12020-019-02023-7. Epub 2019 Aug 1.


The purpose of this article will be to review the basics of thyroid hormone therapy, including various thyroid hormone formulations, the institution and monitoring of thyroid hormone therapy, adverse effects of overtreatment, the management of patients with persistent symptoms despite normal thyroid function tests, and potential new innovations in thyroid hormone therapy. The conclusions support the necessity to personalize thyroid hormone replacement therapy in hypothyroid patients.

Publication types

  • Review

MeSH terms

  • Hormone Replacement Therapy
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / diagnosis
  • Hypothyroidism / drug therapy*
  • Hypothyroidism / etiology
  • Thyroid Hormones / therapeutic use*
  • Thyrotropin / blood
  • Treatment Failure


  • Thyroid Hormones
  • Thyrotropin