Medial prefrontal cortex in neurological diseases

Physiol Genomics. 2019 Sep 1;51(9):432-442. doi: 10.1152/physiolgenomics.00006.2019. Epub 2019 Aug 2.


The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

Keywords: cortical region; medial prefrontal cortex; neural circuit; neurological disease; pathophysiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / physiopathology*
  • Animals
  • Anxiety Disorders / physiopathology*
  • Autism Spectrum Disorder / physiopathology*
  • Depression / physiopathology
  • Humans
  • Parkinson Disease / physiopathology*
  • Prefrontal Cortex / anatomy & histology
  • Prefrontal Cortex / cytology
  • Prefrontal Cortex / physiopathology*
  • Schizophrenia / physiopathology*
  • Substance-Related Disorders / physiopathology*