Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells

Int J Mol Sci. 2019 Aug 1;20(15):3763. doi: 10.3390/ijms20153763.


Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.

Keywords: U937 cell line; folate; pro-monocytes; pyridoxine; riboflavin; vitamin B complex; vitamin B2; vitamin B6; vitamin B9.

MeSH terms

  • Adult
  • Anticarcinogenic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Folic Acid / pharmacology*
  • Humans
  • Lymphoma / drug therapy*
  • Lymphoma / pathology
  • Male
  • Riboflavin / pharmacology*
  • Vitamin B 6 / pharmacology*


  • Anticarcinogenic Agents
  • Vitamin B 6
  • Folic Acid
  • Riboflavin