Sleep Pharmacogenetics: The Promise of Precision Medicine

Sleep Med Clin. 2019 Sep;14(3):317-331. doi: 10.1016/j.jsmc.2019.05.003. Epub 2019 Jun 14.


Pharmacogenetics is the branch of personalized medicine concerned with the variability in drug response occurring because of heredity. Advances in genetics research, and decreasing costs of gene sequencing, are promoting tremendous growth in pharmacogenetics in all areas of medicine, including sleep medicine. This article reviews the body of research indicating that there are genetic variations that affect the therapeutic actions and adverse effects of agents used for the treatment of sleep disorders to show the potential of pharmacogenetics to improve the clinical practice of sleep medicine.

Keywords: Genetic polymorphism; Pharmacogenetics; Sleep disorder.

Publication types

  • Review

MeSH terms

  • Humans
  • Pharmacogenetics*
  • Precision Medicine*
  • Sleep Wake Disorders / drug therapy*