Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience

Open Forum Infect Dis. 2019 Aug 1;6(8):ofz327. doi: 10.1093/ofid/ofz327.


Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

Keywords: bacterial infection; metagenomic next-generation sequencing; viral infection.