The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder

Ali Ahmadalipour; Leila Mehdizadeh Fanid; Narges Zeinalzadeh; Maedeh Alizadeh; Helaleh Vaezi; Zahra Hassanpour Aydinlou; Seyed Gholamreza Noorazar

doi:10.1016/j.ygeno.2019.07.024

The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder

Genomics. 2020 Mar;112(2):1330-1334. doi: 10.1016/j.ygeno.2019.07.024. Epub 2019 Aug 1.

Authors

Ali Ahmadalipour¹, Leila Mehdizadeh Fanid², Narges Zeinalzadeh³, Maedeh Alizadeh⁴, Helaleh Vaezi⁵, Zahra Hassanpour Aydinlou⁵, Seyed Gholamreza Noorazar⁶

Affiliations

¹ Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: alipoura@tbzmed.ac.ir.
² Cognitive Neuroscience, Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Division of cognitive Neuroscience, Department of Psychology, Faculty of Education and Psychology, University of Tabriz, Tabriz, Iran.
³ Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran. Electronic address: zeinalzadeh@tabrizu.ac.ir.
⁴ Department of Nursing, Maragheh University of Medical Sciences, Maragheh, Iran.
⁵ Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
⁶ Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 31377429
DOI: 10.1016/j.ygeno.2019.07.024

Abstract

Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P = .04) and genotype distribution (P = .04) of the FAAH rs2295633 between ADHD cases and controls. The ADHD children appeared to have less of TT genotype (OR 0.396, 95% CI 0.178-0.884, p = .024) and T allele (OR 0.658, 95% CI 0.440-0.982, p = .04). To our best knowledge, this is the first statistical significant association between FAAH rs2295633 genotype and ADHD disorder. Larger sample sizes and functional studies are warranted to explore the clinical utility of FAAH genotyping as a possible marker for increased ADHD risk in children.

Keywords: ADHD; Attention deficit hyperactivity disorder; Endocannabinoids; FAAH gene; Genetic association; rs2295633.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amidohydrolases / genetics*
Attention Deficit Disorder with Hyperactivity / genetics*
Child
Female
Humans
Male
Polymorphism, Single Nucleotide*

Substances

Amidohydrolases
fatty-acid amide hydrolase