Lipid rafts in psychiatry

Adv Pharmacol. 2019:86:21-45. doi: 10.1016/bs.apha.2019.04.001. Epub 2019 May 2.

Abstract

Lipid microenvironments in the plasma membrane are known to influence many signal transduction pathways. Several of those pathways are critical for both the etiology and treatment of depression. Further, several signaling proteins are modified, covalently, by lipids, a process that alters their interface with the microenvironments mentioned above. This review presents a brief discussion of the interface of the above elements as well as a discussion about the participation of lipids and lipid moieties in the action of antidepressants.

Keywords: Antidepressants; Gα(s); Lipid rafts; Lipids; Signal transduction pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biogenic Monoamines / metabolism
  • Depression / metabolism
  • GTP-Binding Protein alpha Subunits / metabolism
  • Humans
  • Membrane Microdomains / metabolism*
  • Psychiatry*
  • Signal Transduction

Substances

  • Biogenic Monoamines
  • GTP-Binding Protein alpha Subunits