Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives

Food Chem. 2019 Dec 15;301:125222. doi: 10.1016/j.foodchem.2019.125222. Epub 2019 Jul 22.


Collagen hydrolysates (peptides) derived from food processing byproducts have been used to produce commercially valuable food ingredients due to their potential to trigger certain desirable physiological responses in the body. Low-molecular-weight (LMW) collagen hydrolysates are generally thought to exert better bioactivities than their larger counterparts. However, the preparation of LMW collagen hydrolysates is often impeded by their special structure, cross-linking, and hydroxyproline. This review briefly introduces the motivation of the food industry to prepare LMW collagen hydrolysate from food processing byproducts. We further summarize recent progress on the preparation of LMW collagen hydrolysates and methods to determine the molecular weight. We then discuss the challenges and then provide perspectives on future directions in preparing LMW collagen hydrolysates.

Keywords: Collagen peptides; Cross-links; Hydrolysates; Hydroxyproline.

Publication types

  • Review

MeSH terms

  • Animals
  • Collagen / chemistry*
  • Food-Processing Industry / methods*
  • Hydroxyproline / chemistry
  • Molecular Weight
  • Peptides / chemistry
  • Protein Hydrolysates / chemistry*


  • Peptides
  • Protein Hydrolysates
  • Collagen
  • Hydroxyproline