Dietary lipids and environmental xenobiotics as risk factors for prostate cancer: The role of cytochrome P450

Abstract

Prostate cancer is one of the most common malignant neoplasms in men. Because of the increase in the number of cases as well as development of cancers resistant to conventional therapy, identification of the new molecular targets for the treatment and prevention is of great importance. For this purpose, many studies are aimed on revealing of molecular mechanisms of prostate cancer development. In this process, dietary lipids and environmental xenobiotics are largely involved and are considered as risk factors. A wide range of endogenous (cholesterol, polyunsaturated fatty acids, etc.) and exogenous (pollutants, drugs) compounds are metabolized in the human organism by cytochrome P450. From other hand, these compounds may alter cytochrome P450 expression levels, especially in prostate, which, in turn, affects cell metabolism. Cytochrome P450 is a member of signaling pathways, regulating cell cycle, apoptosis, invasion and adhesion. Hence, cytochrome P450 most probably plays the important role in initiation and progression of prostate cancer. Based on that, cytochrome P450 enzymes are considered as potential targets for the targeted therapy and prevention, and might serve as specific markers of malignant growth.

Keywords: Cholesterol; Cytochrome P450; Polyunsaturated fatty acids; Prostate cancer; Xenobiotics.