Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance

Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01186-19. doi: 10.1128/AAC.01186-19. Print 2019 Oct.


The quorum-sensing (QS) system is an intercellular cell-cell communication mechanism that controls the expression of genes involved in a variety of cellular processes and that plays critical roles in the adaption and survival of bacteria in their environment. The LuxS/AI-2 QS system, which uses AI-2 (autoinducer-2) as a signal molecule, has been identified in both Gram-negative and Gram-positive bacteria. As one of the important global regulatory networks in bacteria, it responds to fluctuations in the numbers of bacteria and regulates the expression of a number of genes, thus affecting cell behavior. We summarize here the known relationships between the LuxS/AI-2 system and drug resistance, discuss the inhibition of LuxS/AI-2 system as an approach to prevent bacterial resistance, and present new strategies for the treatment of drug-resistant pathogens.

Keywords: LuxS/AI-2 system; bacterial resistance; biofilm formation; efflux pump.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Biofilms / drug effects
  • Gene Expression Regulation, Bacterial / genetics
  • Quorum Sensing / genetics


  • Anti-Bacterial Agents
  • Bacterial Proteins