Case report: lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma

Future Oncol. 2019 Aug;15(24s):13-19. doi: 10.2217/fon-2019-0099. Epub 2019 Aug 6.


We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy.

Keywords: case report; lenvatinib; neoadjuvant; thyroid carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Carcinoma, Papillary / diagnostic imaging
  • Carcinoma, Papillary / drug therapy*
  • Carcinoma, Papillary / pathology
  • Carcinoma, Papillary / surgery
  • Female
  • Humans
  • Iodine Radioisotopes / administration & dosage
  • Neoadjuvant Therapy
  • Phenylurea Compounds / administration & dosage*
  • Quinolines / administration & dosage*
  • Thyroid Neoplasms / diagnostic imaging
  • Thyroid Neoplasms / drug therapy*
  • Thyroid Neoplasms / pathology
  • Thyroid Neoplasms / surgery
  • Thyroidectomy


  • Iodine Radioisotopes
  • Phenylurea Compounds
  • Quinolines
  • lenvatinib