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Review
. 2019 Aug 5;50(3):264-282.
doi: 10.1016/j.devcel.2019.06.003.

The Hippo Signaling Pathway in Development and Disease

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Free PMC article
Review

The Hippo Signaling Pathway in Development and Disease

Yonggang Zheng et al. Dev Cell. .
Free PMC article

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Keywords: NF2; TAZ; TEAD; YAP; actomyosin; adherens junction; cancer; cell polarity; cytoskeleton; growth control; hippo signaling; mechanotransduction; merlin; neurofibromatosis; oncogene; regeneration; scalloped; spectrin; tissue homeostasis; tumor suppressor; yorkie.

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