As bioinert material, silicone has to be modified to display suitable biological properties. Peptides are attractive additives for such a purpose. Most of the time, several steps are needed for the synthesis of the peptide-modified silicone: first the silicone surface is modified to display a reactive function, then a bifunctional spacer can be grafted, and finally, the peptide is attached on the reactive group. However, some other alternatives exist to reduce the number of steps, involving either the synthesis of modified silicones by copolymerization, or the use of silylated peptides. This review present the different pathways and the conjugation chemistries developed so far to afford peptide silicones conjugates.
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