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Multicenter Study
. 2019 Sep;98(Pt A):220-227.
doi: 10.1016/j.yebeh.2019.07.025. Epub 2019 Aug 3.

Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project

Charlene N Rivera Bonet  1 , Bruce Hermann  2 , Cole J Cook  3 , Gyujoon Hwang  3 , Kevin Dabbs  2 , Veena Nair  4 , Courtney Forseth  2 , Jedidiah Mathis  5 , Linda Allen  6 , Dace N Almane  2 , Karina Arkush  7 , Rasmus Birn  8 , Lisa L Conant  6 , Edgar A DeYoe  9 , Elizabeth Felton  2 , Colin J Humphries  6 , Peter Kraegel  6 , Rama Maganti  2 , Andrew Nencka  5 , Onyekachi Nwoke  10 , Manoj Raghavan  6 , Megan Rozman  6 , Umang Shah  7 , Veronica N Sosa  7 , Aaron F Struck  2 , Neelima Tellapragada  4 , Candida Ustine  6 , B Douglas Ward  11 , Vivek Prabhakaran  12 , Jeffrey R Binder  13 , Mary E Meyerand  14
Affiliations
Multicenter Study

Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project

Charlene N Rivera Bonet et al. Epilepsy Behav. 2019 Sep.

Abstract

Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.

Keywords: Big 5 traits; NEO-Five Factor Inventory; Personality; Temporal lobe epilepsy.

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Figures

Figure 1.
Figure 1.. NEO test scores comparison between controls and TLE.
Neuroticism was significantly higher in individuals with TLE. Agreeableness, conscientiousness, extraversion and openness were lower, but not significant different in TLE compared to controls.
Figure 2.
Figure 2.. Partial regression between NEO Neuroticism and age of onset.
Higher neuroticism was associated with earlier age of epilepsy onset. Others = covariates.
Figure 3.
Figure 3.. Correlation between cortical gray matter volume and NEO Neuroticism for TLE participants.
Blue areas represent regions with significant (p<0.05) negative correlations representing decreased volume with increased neuroticism. Results were corrected using Monte-Carlo simulations with a 0.01 threshold (df=43).
Figure 4.
Figure 4.. Partial regression between subcortical gray matter volume and neuroticism.
Lower gray matter volume was associated with increased neuroticism in the (A) left and (B) right hippocampus, and the (C) left amygdala. Others= covariates.
See this image and copyright information in PMC

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