A trial of 5-fluorouracil and Corynebacterium parvum in advanced colorectal carcinoma

Dis Colon Rectum. May-Jun 1979;22(4):223-7. doi: 10.1007/BF02586879.

Abstract

This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administered C. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administered C. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antibodies, Bacterial
  • B-Lymphocytes / immunology
  • Colonic Neoplasms / immunology
  • Colonic Neoplasms / therapy*
  • Female
  • Fluorouracil / therapeutic use*
  • Humans
  • Hypersensitivity, Delayed / immunology
  • Immunoglobulins / analysis
  • Immunotherapy
  • Leukocyte Count
  • Male
  • Middle Aged
  • Propionibacterium acnes / immunology*
  • Prospective Studies
  • Rectal Neoplasms / immunology
  • Rectal Neoplasms / therapy*
  • Skin Tests
  • T-Lymphocytes / immunology

Substances

  • Antibodies, Bacterial
  • Immunoglobulins
  • Fluorouracil