Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. May-Jun 1979;22(4):223-7.
doi: 10.1007/BF02586879.

A Trial of 5-fluorouracil and Corynebacterium Parvum in Advanced Colorectal Carcinoma

Clinical Trial

A Trial of 5-fluorouracil and Corynebacterium Parvum in Advanced Colorectal Carcinoma

I R Gough et al. Dis Colon Rectum. .

Abstract

This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administered C. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administered C. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect.

Similar articles

See all similar articles

Publication types

LinkOut - more resources

Feedback