Mitochondria-hubs for regulating cellular biochemistry: emerging concepts and networks

Open Biol. 2019 Aug 30;9(8):190126. doi: 10.1098/rsob.190126. Epub 2019 Aug 7.


Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to as the powerhouse of the cell due to a central role in energy production. However, modern-day mitochondria are recognized as key players in eukaryotic cell biology and are known to regulate crucial cellular processes, including calcium signalling, cell metabolism and cell death, to name a few. In this review, we will discuss foundational knowledge in mitochondrial biology and provide snapshots of recent advances that showcase how mitochondrial function regulates other cellular responses.

Keywords: metabolism; mitochondria; mitochondrial biogenesis.

MeSH terms

  • Animals
  • Biological Transport
  • Biomarkers
  • Cell Cycle / genetics
  • Cell Differentiation / genetics
  • Energy Metabolism*
  • Gene Expression Regulation*
  • Humans
  • Mitochondria / genetics*
  • Mitochondria / metabolism*
  • Mitochondrial Dynamics
  • Organelle Biogenesis
  • Signal Transduction*


  • Biomarkers