The intestinal microbiota fuelling metabolic inflammation

Nat Rev Immunol. 2020 Jan;20(1):40-54. doi: 10.1038/s41577-019-0198-4. Epub 2019 Aug 6.


Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Dysbiosis / metabolism
  • Gastrointestinal Microbiome*
  • Humans
  • Inflammation / microbiology*
  • Intestinal Mucosa / metabolism
  • Metabolic Diseases / microbiology