Pharmacokinetics of Tranexamic Acid Given as an Intramuscular Injection Compared to Intravenous Infusion in a Swine Model of Ongoing Hemorrhage

Shock. 2020 Jun;53(6):754-760. doi: 10.1097/SHK.0000000000001427.

Abstract

Introduction: Tranexamic acid (TXA) improves survival in traumatic hemorrhage, but difficulty obtaining intravenous (IV) access may limit its use in austere environments, given its incompatibility with blood products. The bioavailability of intramuscular (IM) TXA in a shock state is unknown. We hypothesized that IM and IV administration have similar pharmacokinetics and ability to reverse in vitro hyperfibrinolysis in a swine-controlled hemorrhage model.

Methods: Twelve Yorkshire cross swine were anesthetized, instrumented, and subjected to a 35% controlled hemorrhage, followed by resuscitation. During hemorrhage, they were randomized to receive a 1 g IV TXA infusion over 10 min, 1 g IM TXA in two 5 mL injections, or 10 mL normal saline IM injection as a placebo group to assess model adequacy. Serum TXA concentrations were determined using liquid chromatography-mass spectrometry, and plasma samples supplemented with tissue plasminogen activator (tPA) were analyzed by rotational thromboelastometry.

Results: All animals achieved class III shock. There was no difference in the concentration-time areas under the curve between TXA given by either route. The absolute bioavailability of IM TXA was 97%. IV TXA resulted in a higher peak serum concentration during the infusion, with no subsequent differences. Both IV and IM TXA administration caused complete reversal of in vitro tPA-induced hyperfibrinolysis.

Conclusion: The pharmacokinetics of IM TXA were similar to IV TXA during hemorrhagic shock in our swine model. IV administration resulted in a higher serum concentration only during the infusion, but all levels were able to successfully correct in vitro hyperfibrinolysis. There was no difference in total body exposure to equal doses of TXA between the two routes of administration. IM TXA may prove beneficial in scenarios where difficulty establishing dedicated IV access could otherwise limit or delay its use.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifibrinolytic Agents / administration & dosage
  • Antifibrinolytic Agents / blood
  • Antifibrinolytic Agents / pharmacokinetics*
  • Antifibrinolytic Agents / therapeutic use
  • Disease Models, Animal
  • Female
  • Hemorrhage / blood
  • Hemorrhage / drug therapy*
  • Hemorrhage / physiopathology
  • Infusions, Intravenous
  • Injections, Intramuscular
  • Male
  • Shock, Hemorrhagic / blood
  • Shock, Hemorrhagic / drug therapy
  • Shock, Hemorrhagic / physiopathology
  • Swine
  • Thrombelastography
  • Tranexamic Acid / administration & dosage
  • Tranexamic Acid / blood
  • Tranexamic Acid / pharmacokinetics*
  • Tranexamic Acid / therapeutic use

Substances

  • Antifibrinolytic Agents
  • Tranexamic Acid