Abstract
We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use
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Carbocyanines / chemistry*
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Cell Line, Tumor
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Drug Carriers / chemistry*
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Female
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Fluorescent Dyes / chemistry*
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Gossypol / therapeutic use
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Humans
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Hyaluronic Acid / chemistry
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Mice, SCID
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Micelles
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Nanoparticles / chemistry*
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Neoplasms / diagnostic imaging*
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Optical Imaging / methods*
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Polyethyleneimine / chemistry
Substances
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1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine
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Antineoplastic Agents
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Carbocyanines
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Drug Carriers
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Fluorescent Dyes
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Micelles
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Polyethyleneimine
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Hyaluronic Acid
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Gossypol