Association of Vitamin D Status with Metabolic Syndrome and its Components in Polycystic Ovary Syndrome

Mymensingh Med J. 2019 Jul;28(3):547-552.


Metabolic syndrome (Met-S) and vitamin D deficiency (VDD) are common in polycystic ovary syndrome (PCOS) and hypovitaminosis D in PCOS was found to be associated with Met-S and its components. This cross-sectional study evaluated 110 newly diagnosed women with PCOS randomly recruited from the Endocrinology outpatient department of Mymensingh Medical College Hospital, Bangladesh from January to December 2018 to assess vitamin D status and to explore the relationship of vitamin D status with Met-S and its components. Met-S was diagnosed by using the International Diabetes Federation (IDF) criteria applicable for South Asian women. Serum 25(OH)D was measured by using chemiluminescence immunoassay (CLIA) method and vitamin D status was determined as per The Endocrine Society cut points. Out of 110 PCOS women studied, 44(40%) had Met-S and 72 (65.5%) had vitamin D deficiency. Subjects with Met-S had higher body mass index (BMI), waist circumference (WC), systolic blood pressure (BP), diastolic BP, fasting plasma glucose (FPG), plasma glucose 2 hour after oral glucose tolerance test (PG 2H-OGTT), triglyceride (TG), total and LDL-cholesterol. The mean vitamin D level was lower in Met-S subjects than those without (17.25±5.71 vs. 20.09±7.02, p=0.027). The frequency of VDD was also higher in Met-S group (75% vs. 59.1%, p=0.227). Vitamin D level showed significant positive correlations with PG 2H-OGTT, TG, total and LDL-cholesterol. Age, BMI, WC, systolic BP, diastolic BP, Ferriman Galway score, FPG, HDL cholesterol, testosterone, prolactin, and TSH had no correlations with vitamin D level. Vitamin D may be associated with Met-S in PCOS as Met-S subjects had lower vitamin D level and higher frequency of vitamin D deficiency, and also correlated with some components of Met-S.

MeSH terms

  • Bangladesh
  • Body Mass Index
  • Cross-Sectional Studies
  • Female
  • Humans
  • Metabolic Syndrome* / complications
  • Polycystic Ovary Syndrome* / complications
  • Vitamin D
  • Vitamin D Deficiency* / complications


  • Vitamin D