Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients. 2019 Aug 7;11(8):1822. doi: 10.3390/nu11081822.


To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.

Keywords: C-reactive protein; bisacurone; chronic inflammation; glucose; hemoglobin A1c; high-density cholesterol; profile of mood states; short-form 36-item health survey; turmeric (Curcuma longa L.); turmeronol.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Curcuma / chemistry*
  • Cyclohexanols / administration & dosage
  • Double-Blind Method
  • Humans
  • Hypertension / blood*
  • Inflammation / blood*
  • Mental Health
  • Middle Aged
  • Overweight / blood*
  • Placebos
  • Plant Extracts / pharmacology*
  • Prehypertension / blood
  • Sesquiterpenes / administration & dosage
  • Water


  • Biomarkers
  • Cyclohexanols
  • Placebos
  • Plant Extracts
  • Sesquiterpenes
  • bisacurone
  • Water
  • turmeric extract