Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

Molecules. 2019 Aug 9;24(16):2894. doi: 10.3390/molecules24162894.


Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.

Keywords: antibacterial activity; dendrimers; levofloxacin; synergistic effects.

MeSH terms

  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Bacteria / growth & development*
  • Dendrimers* / chemistry
  • Dendrimers* / pharmacology
  • Drug Synergism
  • Levofloxacin* / agonists
  • Levofloxacin* / chemistry
  • Levofloxacin* / pharmacology


  • Anti-Bacterial Agents
  • Dendrimers
  • Levofloxacin