Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination

S Yoshida; H Naganawa; T Aoyagi; T Takeuchi; H Umezawa

doi:10.7164/antibiotics.41.1015

Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination

J Antibiot (Tokyo). 1988 Aug;41(8):1015-8. doi: 10.7164/antibiotics.41.1015.

Authors

S Yoshida¹, H Naganawa, T Aoyagi, T Takeuchi, H Umezawa

Affiliation

¹ Institute of Microbial Chemistry, Tokyo, Japan.

PMID: 3139602
DOI: 10.7164/antibiotics.41.1015

Abstract

Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase, has been isolated from the culture broth of Streptomyces flavovirens MH499-O'F1. The structure of benadrostin was defined as 8-hydroxy-2H-1,3-benzoxazine-2,4-dione by an analysis of spectral properties and chemical studies of benadrostin and its derivatives.

MeSH terms

Chemical Phenomena
Chemistry
Hydrolysis
Magnetic Resonance Spectroscopy
Methylation
Oxazines* / isolation & purification
Poly(ADP-ribose) Polymerase Inhibitors*
Spectrophotometry, Ultraviolet
Streptomyces / metabolism*

Substances

Oxazines
Poly(ADP-ribose) Polymerase Inhibitors
benadrostin