3'-deoxyadenosine and implantation of delayed blastocysts in mice

J Endocrinol. 1979 Jun;81(3):351-4. doi: 10.1677/joe.0.0810351.

Abstract

Pregnant mice were ovariectomized 3 days after mating and pregnancy was maintained by progesterone treatment. Different regimens of intraperitoneal injections of 3'-deoxyadenosine were applied 3 days after ovariectomy. Repetition of the injections at 3 h intervals induced a significant rate of implantation by delayed blastocysts. Other types of treatment with 3-deoxyadenosine as well as adenosine injections were found to be ineffective. Paradoxically, 3'-deoxyadenosine treatment had an adverse effect on the overall pregnancy rate found at autopsy.

MeSH terms

  • Animals
  • Blastocyst / drug effects
  • Blastocyst / physiology
  • Castration
  • Deoxyadenosines / administration & dosage
  • Deoxyadenosines / pharmacology*
  • Embryo Implantation / drug effects*
  • Embryo Implantation, Delayed / drug effects*
  • Estradiol / pharmacology
  • Female
  • Injections, Intraperitoneal
  • Mice
  • Pregnancy
  • Progesterone / pharmacology

Substances

  • Deoxyadenosines
  • Progesterone
  • Estradiol