Sensory Neurons Drive Anticipatory Immunity

Cell. 2019 Aug 8;178(4):771-773. doi: 10.1016/j.cell.2019.07.012.


Sensory neurons have recently emerged as critical mediators of immunity. Cohen et al. (2019) demonstrate that peripheral neurons utilize reflex arcs in order to rapidly condition the immune response in skin adjacent to the site of infection. This nerve reflex arc generates anticipatory immunity for more effective elimination of the pathogen if later exposed.

Publication types

  • Comment

MeSH terms

  • Immunity, Innate
  • Interneurons
  • Reflex*
  • Sensory Receptor Cells*
  • Skin