Abstract
Chromosomal aberrations and induction of micronuclei were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with benznidazole. The median incidence of micronucleated interphase lymphocytes (20 patients) and chromosomal aberrations (10 patients) increased from control values of 5/1000 and 3% to 11.5/1000 and 6%, respectively, at a significance of P = 0.05.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Nucleus / drug effects
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Chagas Disease / drug therapy*
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Chagas Disease / genetics
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Child
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Child, Preschool
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Chromosome Aberrations*
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DNA Damage*
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Female
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Humans
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Infant
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Lymphocytes / cytology
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Lymphocytes / drug effects
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Male
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Mutagens / adverse effects*
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Nitroimidazoles / adverse effects*
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Nitroimidazoles / therapeutic use
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Trypanocidal Agents / adverse effects*
Substances
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Mutagens
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Nitroimidazoles
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Trypanocidal Agents
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benzonidazole