The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A

Nature. 1988 Oct 13;335(6191):611-7. doi: 10.1038/335611a0.


The vasa gene product of Drosophila melanogaster is required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line and early embryos only. The predicted amino acid sequence is very similar to those of the translation initiation factor eIF-4A and the human nuclear antigen p68.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Drosophila melanogaster / genetics*
  • Eukaryotic Initiation Factor-4A
  • Female
  • Molecular Sequence Data
  • Molecular Structure
  • Morphogenesis*
  • Mutation
  • Oogenesis*
  • Peptide Initiation Factors*


  • Peptide Initiation Factors
  • Eukaryotic Initiation Factor-4A

Associated data

  • GENBANK/X12945
  • GENBANK/X12946