Cardiac MRI and Fibrosis Quantification

Card Electrophysiol Clin. 2019 Sep;11(3):537-549. doi: 10.1016/j.ccep.2019.04.005.


Left atrial fibrosis plays an important role in the pathophysiology of atrial fibrillation. Left atrial ablation is an effective and increasingly used strategy to restore and maintain sinus rhythm in patients with atrial fibrillation. Late gadolinium enhancement (LGE) MRI and custom image analysis software have been used to visualize and quantify preablation atrial fibrosis and postablation scar and new fibrosis formation. This article reviews technical aspects of imaging atrial fibrosis/scar by LGE-MRI; use of atrial fibrosis and scar in predicting outcomes; applications of LGE-MRI to assess ablation lesions and optimize ablation parameters while avoiding collateral damage.

Keywords: Ablation; Atrial fibrillation; Atrial fibrosis; LGE-MRI.

Publication types

  • Review

MeSH terms

  • Atrial Fibrillation* / diagnostic imaging
  • Atrial Fibrillation* / pathology
  • Cardiac Imaging Techniques*
  • Fibrosis
  • Heart / diagnostic imaging*
  • Humans
  • Magnetic Resonance Imaging*
  • Myocardium / pathology*