Normal Hemoglobin A1c Variability in Early Adolescence: Adult Criteria for Prediabetes Should Be Applied with Caution

Megan M Kelsey; Philip S Zeitler; Kimberly Drews; Christine L Chan

doi:10.1016/j.jpeds.2019.07.031

Normal Hemoglobin A1c Variability in Early Adolescence: Adult Criteria for Prediabetes Should Be Applied with Caution

J Pediatr. 2020 Jan:216:232-235. doi: 10.1016/j.jpeds.2019.07.031. Epub 2019 Aug 9.

Authors

Megan M Kelsey¹, Philip S Zeitler², Kimberly Drews³, Christine L Chan²

Affiliations

¹ Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO. Electronic address: megan.kelsey@childrenscolorado.org.
² Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
³ Department of Biostatistics, George Washington University, Seattle, WA.

Abstract

American Diabetes Association adult criteria are used to screen youth for diabetes, but little is known about normal glycemia in youth. In the HEALTHY Study (total n = 8814), hemoglobin A1c was ≥5.7% in 2% of normal weight youth. This suggests need for cautious interpretation of prediabetes hemoglobin A1s in youth.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Adult
Age Factors
Child
Cohort Studies
Female
Glycated Hemoglobin / analysis*
Humans
Male
Prediabetic State / blood*
Prediabetic State / diagnosis*
Reference Values

Substances

Glycated Hemoglobin A

Abstract

Publication types

MeSH terms

Substances

Grants and funding