Low level laser therapy for the patients with painful diabetic peripheral neuropathy - A systematic review

Diabetes Metab Syndr. Jul-Aug 2019;13(4):2667-2670. doi: 10.1016/j.dsx.2019.07.035. Epub 2019 Jul 13.


Background: Low Level Laser Therapy (LLLT) is an emerging treatment modality for management of neuropathic pain. It works by triggering biochemical changes with in cells.

Objective: This systematic review focused on finding evidence on the effectiveness of LLLT on treatment of painful diabetic neuropathy.

Methods: We conducted a systematic review (PubMed, Web of Science, CINAHL and Cochrane) to find the evidence on effectiveness of LLLT on treatment of painful diabetic neuropathy. Randomized and non-randomized studies were included in the review.

Results: A total of 627 studies were screened. After the exclusion criteria (duplicate, animal studies, LLLT for treating other neuralgias) 6 studies were included in the study. The outcome measure that were considered were the difference in pain score and nerve conduction velocity test and quality of life questionnaire.

Conclusion: The evidence obtained shows LLLT has a positive effect in controlling diabetic neuropathic pain.

Publication types

  • Systematic Review

MeSH terms

  • Diabetic Neuropathies / complications*
  • Humans
  • Low-Level Light Therapy / methods*
  • Neuralgia / etiology
  • Neuralgia / therapy*
  • Prognosis
  • Quality of Life*