Cannabinoid CB2 Receptor Functional Variation (Q63R) Is Associated with Multiple Sclerosis in Iranian Subjects

J Mol Neurosci. 2020 Jan;70(1):26-31. doi: 10.1007/s12031-019-01395-9. Epub 2019 Aug 13.


The cannabinoid system has been identified as a critical endogenous regulator of immune homeostasis through immunomodulatory actions. This system is one of the main regulatory systems of the central nervous system (CNS). Variations in the cannabinoid CB2 receptor gene (CNR2) could affect intracellular signaling and reduce system function, which has been associated with an unbalanced immune response and increased risk of a variety of autoimmune inflammatory disorders. The present study investigated the relationship between CNR2 rs35761398 (Q63R) functional variation and multiple sclerosis (MS). A total of 100 Iranian MS patients and 100 healthy controls were enrolled in the study and genotyped through TaqMan assay. The co-dominant, dominant, recessive, over-dominant, and additive inheritance models were analyzed using SNPStats software. A significant genetic association was observed between Q63R polymorphism and MS. The dominant model was accepted as the best inheritance model to fit the data (OR 2.70, 95% CI 1.47-4.97, p = 0.001). The data implied the involvement of the CNR2 gene in susceptibility to MS in Iranian patients.

Keywords: CNR2; Cannabinoid receptor type 2; Iran; Multiple sclerosis; Q63R; Single-nucleotide polymorphism.

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / genetics*
  • Mutation, Missense*
  • Polymorphism, Single Nucleotide*
  • Receptor, Cannabinoid, CB2 / genetics*


  • CNR2 protein, human
  • Receptor, Cannabinoid, CB2