Ceftriaxone Dosing in a Critically Ill Patient With Hypoalbuminemia During Continuous Venous Hemofiltration: Emphasis on Unbound Pharmacokinetics

J Clin Pharmacol. 2020 Jan;60(1):140-142. doi: 10.1002/jcph.1503. Epub 2019 Aug 13.
No abstract available

Keywords: ceftriaxone; continuous venovenous hemofiltration; hypoalbuminemia; pharmacokinetics; unbound plasma concentration.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Ceftriaxone / pharmacokinetics*
  • Ceftriaxone / therapeutic use
  • Critical Illness
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / drug therapy*
  • Escherichia coli Infections / metabolism
  • Female
  • Hemofiltration
  • Humans
  • Hypoalbuminemia / complications*
  • Shock, Septic / complications
  • Shock, Septic / therapy*

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone