Extended-spectrum β-lactamase Enterobacteriaceae (ESBLE) in intensive care units: strong correlation with the ESBLE colonization pressure in patients but not same species

J Hosp Infect. 2020 Jan;104(1):53-56. doi: 10.1016/j.jhin.2019.08.007. Epub 2019 Aug 10.

Abstract

Sink drains of six intensive care units (ICUs) were sampled for screening contamination with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE). A high prevalence (59.4%) of sink drain contamination was observed. Analysing the data by ICU, the ratio 'number of ESBLE species isolated in sink drains/total number of sink drains sampled' was highly correlated (Spearman coefficient: 0.87; P = 0.02) with the ratio 'number of hospitalization days for patients with ESBLE carriage identified within the preceding year/total number of hospitalization days within the preceding year'. Concurrently, the distribution of ESBLE species differed significantly between patients and sink drains.

Keywords: Bacterial dissemination; Colonization pressure; Extended-spectrum-β-lactamase; Klebsiella pneumoniae; Sink drain.

MeSH terms

  • Carbapenem-Resistant Enterobacteriaceae
  • Carrier State / epidemiology
  • Citrobacter / isolation & purification
  • Cross Infection / epidemiology
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / epidemiology
  • Enterobacteriaceae Infections / microbiology*
  • France / epidemiology
  • Humans
  • Intensive Care Units / statistics & numerical data*
  • Klebsiella pneumoniae / isolation & purification
  • Surveys and Questionnaires
  • beta-Lactamases / drug effects
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases