Replays of spatial memories suppress topological fluctuations in cognitive map

Netw Neurosci. 2019 Jul 1;3(3):707-724. doi: 10.1162/netn_a_00076. eCollection 2019.

Abstract

The spiking activity of the hippocampal place cells plays a key role in producing and sustaining an internalized representation of the ambient space-a cognitive map. These cells do not only exhibit location-specific spiking during navigation, but also may rapidly replay the navigated routs through endogenous dynamics of the hippocampal network. Physiologically, such reactivations are viewed as manifestations of "memory replays" that help to learn new information and to consolidate previously acquired memories by reinforcing synapses in the parahippocampal networks. Below we propose a computational model of these processes that allows assessing the effect of replays on acquiring a robust topological map of the environment and demonstrate that replays may play a key role in stabilizing the hippocampal representation of space.

Keywords: Hippocampal replays; Learning and memory; Transient networks; Zigzag homology theory.