Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: A systematic review

Neurosci Biobehav Rev. 2019 Oct:105:231-248. doi: 10.1016/j.neubiorev.2019.07.004. Epub 2019 Aug 11.


In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.

Keywords: Anterior commissure; Commissures; Corpus callosum agenesis; Functional connectivity; Homotopic connectivity; Interhemispheric connectivity; Split-brain.

Publication types

  • Research Support, N.I.H., Extramural
  • Systematic Review

MeSH terms

  • Agenesis of Corpus Callosum / pathology
  • Agenesis of Corpus Callosum / physiopathology*
  • Brain / pathology
  • Brain / physiopathology*
  • Connectome*
  • Corpus Callosum / pathology
  • Corpus Callosum / physiopathology*
  • Corpus Callosum / surgery
  • Humans
  • Nerve Net / pathology
  • Nerve Net / physiopathology*
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology*