Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Cells. 2019 Aug 13;8(8):890. doi: 10.3390/cells8080890.


Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.

Keywords: ADP-ribosylation; ARTD; Carbohydrate metabolism; NAD+; NAM; NMN; NR; PARP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP-Ribosylation
  • Adenosine Diphosphate Ribose / metabolism*
  • Animals
  • Carbohydrate Metabolism / physiology
  • Cell Line
  • DNA Damage / physiology
  • Glucose / metabolism*
  • Humans
  • Metabolic Networks and Pathways / physiology
  • Mice
  • NAD / metabolism*
  • Organelles / metabolism*


  • NAD
  • Adenosine Diphosphate Ribose
  • Glucose