Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China

doi:10.2147/OTT.S210103

. 2019 Jul 23:12:5947-5953.

doi: 10.2147/OTT.S210103. eCollection 2019.

Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China

Jin-Rong Yang¹, Guo-Chong Chen¹, Jia-Ying Xu², Chen-Jie Ling¹, Na Yu³, Jing Yang⁴, Da-Xiong Zeng⁵, Min-Jing Gu⁶, Da-Peng Li⁶, Yu-Song Zhang³, Li-Qiang Qin¹

Affiliations

¹ Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215123, People's Republic of China.
² Institute of Quantitative Biology and Medicine, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, People's Republic of China.
³ Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, People's Republic of China.
⁴ Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.
⁵ Department of Respiration, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.
⁶ Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.

PMID: 31413592
PMCID: PMC6662513
DOI: 10.2147/OTT.S210103

Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China

Jin-Rong Yang et al. Onco Targets Ther. 2019.

. 2019 Jul 23:12:5947-5953.

doi: 10.2147/OTT.S210103. eCollection 2019.

Authors

Jin-Rong Yang¹, Guo-Chong Chen¹, Jia-Ying Xu², Chen-Jie Ling¹, Na Yu³, Jing Yang⁴, Da-Xiong Zeng⁵, Min-Jing Gu⁶, Da-Peng Li⁶, Yu-Song Zhang³, Li-Qiang Qin¹

Affiliations

¹ Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215123, People's Republic of China.
² Institute of Quantitative Biology and Medicine, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, People's Republic of China.
³ Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, People's Republic of China.
⁴ Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.
⁵ Department of Respiration, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.
⁶ Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215031, People's Republic of China.

PMID: 31413592
PMCID: PMC6662513
DOI: 10.2147/OTT.S210103

Abstract

Purpose: Non-small-cell lung cancer (NSCLC) is the most diagnosed lung cancer and is associated with poor prognosis. This study aimed to analyze whether fasting blood glucose (FBG) levels could provide prognostic information in Chinese patients with NSCLC, using the Suzhou Lung Cancer Survival study.

Patients and methods: A prospective cohort study of adult patients with primary NSCLC was performed. The patients who were hospitalized between January 2016 and April 2018 in two hospitals affiliated with Soochow University were recruited. Patient information, including lifestyle habits and clinical and laboratory data, were collected through face-to-face interviews and evaluation of medical records. Follow-up was initiated from the date of patient enrollment until May 8, 2018 or until patient death. The long-term survival of patients was assessed every 6 months. Patient vital status was confirmed by using hospital records, telephone interview, or local death registration system. Cox proportional hazards regression was used to estimate hazard ratio and 95% confidence interval (CI) for death, with adjustment for cancer stage, medical treatments, smoking, and other potential confounders.

Results: A total of 387 patients were included in the analysis, and the numbers (percentages) of patients with stages I, II, III, and IV NSCLC were 53 (13.7%), 41 (10.6%), 64 (16.5%), and 215 (55.6%), respectively. The median duration of follow-up was 19.1 months. Compared with patients in the second tertile of FBG, the HRs for mortality were 2.16 (95% CI: 1.26-3.73) and 1.87 (95% CI: 1.03-3.42) for those in the lowest one and diabetic group, respectively. Subgroup analysis according to various patient characteristics confirmed these associations.

Conclusion: Diabetes and low FBG could be important predictors of death in patients with NSCLC. Maintaining appropriate blood glucose levels may improve prognosis in patients with NSCLC.

Keywords: diabetes; fasting blood glucose; non-small cell lung cancer; survival.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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References

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[1] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492 - DOI - PubMed

[2] Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492 - DOI - PubMed

[3] Ettinger DS, Wood DE, Aisner DL, et al. Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2017;15(4):504–535. - PubMed

[4] Ettinger DS, Wood DE, Aisner DL, et al. Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2017;15(4):504–535. - PubMed

[5] Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer: a decade of progress. Chest. 2002;122(3):1037–1057. doi:10.1378/chest.122.3.1037 - DOI - PubMed

[6] Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer: a decade of progress. Chest. 2002;122(3):1037–1057. doi:10.1378/chest.122.3.1037 - DOI - PubMed

[7] Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P. Impact of comorbidity on lung cancer survival. Int J Cancer. 2003;103(6):792–802. doi:10.1002/ijc.10882 - DOI - PubMed

[8] Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P. Impact of comorbidity on lung cancer survival. Int J Cancer. 2003;103(6):792–802. doi:10.1002/ijc.10882 - DOI - PubMed

[9] Barone BB, Yeh HC, Snyder CF, et al. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. Jama. 2008;300(23):2754–2764. doi:10.1001/jama.2008.824 - DOI - PMC - PubMed

[10] Barone BB, Yeh HC, Snyder CF, et al. Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. Jama. 2008;300(23):2754–2764. doi:10.1001/jama.2008.824 - DOI - PMC - PubMed

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Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China

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Fasting blood glucose levels and prognosis in patients with non-small-cell lung cancer: a prospective cohort study in China

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