Melanogenesis in Cryptococcus neoformans

J Gen Microbiol. 1988 Apr;134(4):1037-41. doi: 10.1099/00221287-134-4-1037.


Melanogenesis in Cryptococcus neoformans begins with the oxidation of dihydroxyphenylalanine by the enzyme phenol oxidase. The succeeding steps are very rapid. Two intermediates, dopachrome and 5,6-dihydroxyindole, have been isolated and characterized by high performance liquid chromatography. A pathway of melanin formation in C. neoformans is proposed, based on the presence of these intermediates.

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid
  • Cryptococcus / metabolism*
  • Cryptococcus neoformans / metabolism*
  • Dihydroxyphenylalanine / metabolism
  • Melanins / biosynthesis*


  • Melanins
  • Dihydroxyphenylalanine