Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under-/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check-ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of -0.03 kg (95% CI: -0.11, 0.06) among under-/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under-/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG.
Keywords: ALSPAC; Endocrine disruptors; Gestational weight gain; Perfluoroalkyl substances; Perfluorohexane sulfonic acid (PFHxS); Perfluorononanoic acid (PFNA); Perfluorooctane sulfonic acid (PFOS); Perfluorooctanoic acid (PFOA).
Copyright © 2019 Elsevier Inc. All rights reserved.
Conflict of interest statement
Conflict of interest
Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain.Int J Environ Res Public Health. 2016 Jan 20;13(1):146. doi: 10.3390/ijerph13010146. Int J Environ Res Public Health. 2016. PMID: 26805861 Free PMC article.
Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys.Int J Hyg Environ Health. 2019 Jun;222(5):889-895. doi: 10.1016/j.ijheh.2019.03.008. Epub 2019 Apr 9. Int J Hyg Environ Health. 2019. PMID: 30975573
Variability of perfluoroalkyl substance concentrations in pregnant women by socio-demographic and dietary factors in a Spanish birth cohort.Environ Int. 2016 Jul-Aug;92-93:357-65. doi: 10.1016/j.envint.2016.04.004. Epub 2016 Apr 29. Environ Int. 2016. PMID: 27132161
Association between in utero perfluoroalkyl substance exposure and anti-Müllerian hormone levels in adolescent females in a British cohort.Environ Res. 2019 Oct;177:108585. doi: 10.1016/j.envres.2019.108585. Epub 2019 Jul 18. Environ Res. 2019. PMID: 31376627
Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies.Environ Int. 2017 Feb;99:15-28. doi: 10.1016/j.envint.2016.10.015. Epub 2016 Nov 22. Environ Int. 2017. PMID: 27884404 Review.
- MR/M009351/1/MRC_/Medical Research Council/United Kingdom
- MC_PC_15018/MRC_/Medical Research Council/United Kingdom
- WT_/Wellcome Trust/United Kingdom
- 102215/2/13/2/WT_/Wellcome Trust/United Kingdom
- G9815508/MRC_/Medical Research Council/United Kingdom