Skin immunity and its dysregulation in psoriasis

Cell Cycle. 2019 Oct;18(20):2581-2589. doi: 10.1080/15384101.2019.1653099. Epub 2019 Aug 15.


The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.

Keywords: Psoriasis; biologic therapies; cytokines; immunity; lymphocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / antagonists & inhibitors
  • Cytokines / chemistry
  • Cytokines / immunology
  • Humans
  • Immunity, Innate*
  • Mice
  • Molecular Targeted Therapy / methods
  • Psoriasis / drug therapy
  • Psoriasis / immunology*
  • Psoriasis / pathology*
  • Skin / immunology*
  • T-Lymphocytes / immunology


  • Cytokines

Grants and funding

This work has been supported by the Medical Research Council (to GM), Associazione Italiana per la Ricerca contro il Cancro (AIRC) to GM [IG#20473 (2018-2022)], Fondazione Luigi Maria Monti IDI-IRCCS (R.C. to M.M., M.A.P, G.M.), Ministry of Health & MAECI Italy-China Science and Technology Cooperation [#PGR00961] cooperation grant. Work has been also supported by Regione Lazio through LazioInnova Progetto Gruppo di Ricerca n [85-2017-14986].